Targeting the interaction between long noncoding RNA XR_001779380 and Prdm1 to enhance IFN-γ immunity in murine neonatal intestinal epithelial cells

Targeting the interaction between long noncoding RNA XR_001779380 and Prdm1 to enhance IFN-γ immunity in murine neonatal intestinal epithelial cells

ABSTRACT Intestinal epithelial cells (IECs) serve as the front line of host defense in the intestine, with IFN signaling playing a critical role in regulating epithelial cell-intrinsic defense against intracellular pathogens. However, IFN-γ-mediated antimicrobial defense is usually reduced in the ga...

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Bibliographic Details
Main Authors: Kehua Jin, Ai-Yu Gong, Shuhong Wang, Gislaine A. Martins, Juliane K. Strauss-Soukup, Roberta M. O'Connor, Xian-Ming Chen
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:mBio
Subjects:
Prdm1
IFN-gamma
antisense oligonucleotides
intestinal epithelium
neonates
LncRNAs
Online Access:https://journals.asm.org/doi/10.1128/mbio.00773-25
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https://journals.asm.org/doi/10.1128/mbio.00773-25

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