Batf3-cDC1 control Th1 and fungicidal responses during cryptococcal meningitis: is this enough to control meningitis?
ABSTRACT Dendritic cells are crucial for bridging innate and adaptive immunity. Cryptococcosis, caused by Cryptococcus neoformans and Cryptococcus gattii, is responsible for >15% of AIDS-related deaths. A recent study by Xu et al. showed that Batf3-dependent conventional type 1 dendritic (cDC1) c...
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American Society for Microbiology
2024-10-01
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| Series: | mBio |
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| Online Access: | https://journals.asm.org/doi/10.1128/mbio.00375-24 |
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| author | Carolina Coelho |
| author_facet | Carolina Coelho |
| author_sort | Carolina Coelho |
| collection | DOAJ |
| description | ABSTRACT Dendritic cells are crucial for bridging innate and adaptive immunity. Cryptococcosis, caused by Cryptococcus neoformans and Cryptococcus gattii, is responsible for >15% of AIDS-related deaths. A recent study by Xu et al. showed that Batf3-dependent conventional type 1 dendritic (cDC1) cells are key players in generating IFNγ+ CD4+ T cell and fungicidal lung and brain tissue-resident responses during murine cryptococcosis, contributing to fungal clearance in the lungs and brain of mice (J. Xu, R. Hissong, R. Bareis, A. Creech, et al., mBio 15:e02853-23, 2024, https://doi.org/10.1128/mbio.02853-23). However, despite their critical role, the depletion of Batf3-dependent cDC1 cells did not significantly alter overall mouse survival or disease progression, highlighting the complex immune regulation required to survive cryptococcal infection and the need for further research in medical mycology. |
| format | Article |
| id | doaj-art-e2006d8368f941f2be3f2188ab7602c0 |
| institution | OA Journals |
| issn | 2150-7511 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj-art-e2006d8368f941f2be3f2188ab7602c02025-08-20T02:16:49ZengAmerican Society for MicrobiologymBio2150-75112024-10-01151010.1128/mbio.00375-24Batf3-cDC1 control Th1 and fungicidal responses during cryptococcal meningitis: is this enough to control meningitis?Carolina Coelho0MRC Centre for Medical Mycology at University of Exeter, University of Exeter, Exeter, United KingdomABSTRACT Dendritic cells are crucial for bridging innate and adaptive immunity. Cryptococcosis, caused by Cryptococcus neoformans and Cryptococcus gattii, is responsible for >15% of AIDS-related deaths. A recent study by Xu et al. showed that Batf3-dependent conventional type 1 dendritic (cDC1) cells are key players in generating IFNγ+ CD4+ T cell and fungicidal lung and brain tissue-resident responses during murine cryptococcosis, contributing to fungal clearance in the lungs and brain of mice (J. Xu, R. Hissong, R. Bareis, A. Creech, et al., mBio 15:e02853-23, 2024, https://doi.org/10.1128/mbio.02853-23). However, despite their critical role, the depletion of Batf3-dependent cDC1 cells did not significantly alter overall mouse survival or disease progression, highlighting the complex immune regulation required to survive cryptococcal infection and the need for further research in medical mycology.https://journals.asm.org/doi/10.1128/mbio.00375-24dendritic cellscDC1cDC2Batf3Cryptococcusfungal |
| spellingShingle | Carolina Coelho Batf3-cDC1 control Th1 and fungicidal responses during cryptococcal meningitis: is this enough to control meningitis? mBio dendritic cells cDC1 cDC2 Batf3 Cryptococcus fungal |
| title | Batf3-cDC1 control Th1 and fungicidal responses during cryptococcal meningitis: is this enough to control meningitis? |
| title_full | Batf3-cDC1 control Th1 and fungicidal responses during cryptococcal meningitis: is this enough to control meningitis? |
| title_fullStr | Batf3-cDC1 control Th1 and fungicidal responses during cryptococcal meningitis: is this enough to control meningitis? |
| title_full_unstemmed | Batf3-cDC1 control Th1 and fungicidal responses during cryptococcal meningitis: is this enough to control meningitis? |
| title_short | Batf3-cDC1 control Th1 and fungicidal responses during cryptococcal meningitis: is this enough to control meningitis? |
| title_sort | batf3 cdc1 control th1 and fungicidal responses during cryptococcal meningitis is this enough to control meningitis |
| topic | dendritic cells cDC1 cDC2 Batf3 Cryptococcus fungal |
| url | https://journals.asm.org/doi/10.1128/mbio.00375-24 |
| work_keys_str_mv | AT carolinacoelho batf3cdc1controlth1andfungicidalresponsesduringcryptococcalmeningitisisthisenoughtocontrolmeningitis |