PD-1/PD-L1 inhibitors plus chemotherapy versus chemotherapy alone as the first line treatment for advanced biliary tract cancer: a pooled analysis of KEYNOTE-966 and TOPAZ-1 trails

PD-1/PD-L1 inhibitors plus chemotherapy versus chemotherapy alone as the first line treatment for advanced biliary tract cancer: a pooled analysis of KEYNOTE-966 and TOPAZ-1 trails

Abstract Background The efficacy of PD-1/PD-L1 inhibitors plus chemotherapy (PIC) as a first-line treatment for advanced biliary tract cancer (BTC) remains controversial, given inconsistent findings regarding survival benefits and safety concerns. This meta-analysis systematically evaluates the safe...

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Bibliographic Details
Main Authors: Jiashou Wang, Yun Xu, Bo Hong, Qingjian Hou, Wenying Chen, Wenxiong Zhang, Wen Zheng
Format: Article
Language:English
Published: BMC 2025-06-01
Series:World Journal of Surgical Oncology
Subjects:
PD-1/PD-L1 inhibitors
Chemotherapy
Biliary tract cancer
Meta-analysis
Randomized controlled trials
Online Access:https://doi.org/10.1186/s12957-025-03877-0
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https://doi.org/10.1186/s12957-025-03877-0

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