FAM136A depletion induces mitochondrial stress and reduces mitochondrial membrane potential and ATP production

FAM136A deficiency has been associated with Ménière's disease. However, the underlying mechanism of action of this protein remains unclear. We hypothesized that FAM136A functions in maintaining mitochondria, even in HepG2 cells. To better characterize FAM136A function, we analyzed the cellular...

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Bibliographic Details
Main Authors: Yushi Otsuka, Masato Yano
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:FEBS Open Bio
Subjects:
Online Access:https://doi.org/10.1002/2211-5463.13967
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