SARS-CoV-2 viral proteins trigger pain via TLR2/4-MyD88 pathway

SARS-CoV-2 viral proteins trigger pain via TLR2/4-MyD88 pathway

Somatosensory disorders, especially pain, are prominent symptoms of COVID-19. Except for the viral infection process, SARS-CoV-2 viral proteins might be directly sensed by corresponding receptors, thereby triggering nociceptive signals in the dorsal root ganglion (DRG) and spinal dorsal horn (SDH)....

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Bibliographic Details
Main Authors: Wenliang Su, Xinrui Wang, Minghui Gu, Qiwei Zheng, Jiawen Yu, Dongliang Mu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
SARS-CoV-2
TLR2
TLR4
MyD88
pain
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2025.1163636/full
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