Podocyte dysfunction driven by heme in sickle-cell nephropathy

Podocyte dysfunction driven by heme in sickle-cell nephropathy

Abstract Sickle-cell disease (SCD) is characterized by vaso-occlusive crises and chronic hemolytic anemia, leading to tissue damage affecting various organs, including the kidneys. Hemolysis contributes to sickle-cell nephropathy (SCN) but the molecular mechanisms underlying the intravascular hemoly...

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Bibliographic Details
Main Authors: Chloé Ben Ali, Antoine Morel, Marion Morvan, Anissa Moktefi, Kim-Anh Nguyen-Peyre, Margaux Van Wynsberghe, Hamza Sakhi, Pablo Bartolucci, Vincent Audard, Carole Hénique
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Hemolysis
Heme
Podocyte
Oxidative stress
Cellular stress
Online Access:https://doi.org/10.1038/s41598-025-09220-7
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https://doi.org/10.1038/s41598-025-09220-7

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