Quantitative Systems Toxicology Modeling of Acetaminophen Pharmacokinetics and Hepatic Biomarkers After Overdoses of Extended‐Release and Immediate‐Release Formulations in Adults With Chronic Alcohol Use or Low Glutathione

Quantitative Systems Toxicology Modeling of Acetaminophen Pharmacokinetics and Hepatic Biomarkers After Overdoses of Extended‐Release and Immediate‐Release Formulations in Adults With Chronic Alcohol Use or Low Glutathione

ABSTRACT Acetaminophen (APAP), an over‐the‐counter analgesic and antipyretic, can cause hepatotoxicity when ingested in large overdoses. APAP has multiple formulations including immediate‐release (IR) and extended‐release (ER) preparations. A recently published consensus statement on the management...

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Bibliographic Details
Main Authors: Kyunghee Yang, James J. Beaudoin, Brett A. Howell, James Mullin, Elham Amini, John C. K. Lai, Cathy K. Gelotte, Sury Sista, Evren Atillasoy
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:CPT: Pharmacometrics & Systems Pharmacology
Subjects:
acetaminophen
extended release
liver safety
quantitative systems toxicology modeling
Online Access:https://doi.org/10.1002/psp4.70045
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https://doi.org/10.1002/psp4.70045

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