VSV∆M51 drives CD8+ T cell-mediated tumour regression through infection of both cancer and non-cancer cells

VSV∆M51 drives CD8+ T cell-mediated tumour regression through infection of both cancer and non-cancer cells

Abstract Oncolytic viruses (OV) are designed to selectively infect and kill cancer cells, while simultaneously eliciting antitumour immunity. The mechanism is expected to originate from infected cancer cells. However, recent reports of tumour regression unaccompanied by cancer cell infection suggest...

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Main Authors: Jahanara Rajwani, Daniil Vishnevskiy, Madison Turk, Victor Naumenko, Chris Gafuik, Dae-Sun Kim, Laura K. Mah, Shannon Snelling, Gerone A. Gonzales, Jingna Xue, Ayan Chanda, Kyle G. Potts, Hayley M. Todesco, Keith C. K. Lau, Karys M. Hildebrand, Jennifer A. Chan, Shan Liao, Michael J. Monument, Martin Hyrcza, Pinaki Bose, Craig N. Jenne, Johnathan Canton, Franz J. Zemp, Douglas J. Mahoney
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54111-6
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https://doi.org/10.1038/s41467-024-54111-6

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