Quantification and discovery of sequence determinants of protein‐per‐mRNA amount in 29 human tissues

Quantification and discovery of sequence determinants of protein‐per‐mRNA amount in 29 human tissues

Abstract Despite their importance in determining protein abundance, a comprehensive catalogue of sequence features controlling protein‐to‐mRNA (PTR) ratios and a quantification of their effects are still lacking. Here, we quantified PTR ratios for 11,575 proteins across 29 human tissues using matche...

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Main Authors: Basak Eraslan, Dongxue Wang, Mirjana Gusic, Holger Prokisch, Björn M Hallström, Mathias Uhlén, Anna Asplund, Frederik Pontén, Thomas Wieland, Thomas Hopf, Hannes Hahne, Bernhard Kuster, Julien Gagneur
Format: Article
Language:English
Published: Springer Nature 2019-02-01
Series:Molecular Systems Biology
Subjects:
codon usage
mRNA sequence motifs
proteomics
transcriptomics
translational control
Online Access:https://doi.org/10.15252/msb.20188513
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https://doi.org/10.15252/msb.20188513

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