Novel Quinoline- and Naphthalene-Incorporated Hydrazineylidene–Propenamide Analogues as Antidiabetic Agents: Design, Synthesis, and Computational Studies

Novel Quinoline- and Naphthalene-Incorporated Hydrazineylidene–Propenamide Analogues as Antidiabetic Agents: Design, Synthesis, and Computational Studies

<b>Background:</b> Type 2 diabetes has become a significant global health challenge. Numerous drugs have been developed to treat the condition, either as standalone therapies or in combination when glycemic control cannot be achieved with a single medication. As existing treatments often...

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Main Authors: Osama Alharbi, Wael H. Alsaedi, Mosa Alsehli, Saif H. Althagafi, Hussam Y. Alharbi, Yazeed M. Asiri, Ramith Ramu, Mohammed Al-Ghorbani
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Pharmaceuticals
Subjects:
quinoline
naphthalene
α-glycosidase
α-amylase and aldose reductase enzyme inhibitions
molecular docking simulation
molecular dynamics simulation
Online Access:https://www.mdpi.com/1424-8247/17/12/1692
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