t-RNA mediates provirus deletion in HIV-infected cells

Abstract Background In the early phase of HIV infection, as studied in vitro, high levels of unintegrated (both linear and circular) and integrated (provirus) forms of viral DNA are seen, and cells produce high levels of virus. In time, the level of unintegrated DNA declines, followed by a progressi...

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Bibliographic Details
Main Authors: Corrado Gurgo, Genoveffa Franchini
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Retrovirology
Subjects:
Online Access:https://doi.org/10.1186/s12977-025-00667-0
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