Translocation of SIRT6 promotes glycolysis reprogramming to exacerbate diabetic angiopathy

Translocation of SIRT6 promotes glycolysis reprogramming to exacerbate diabetic angiopathy

Diabetic angiopathy, a major complication of type 2 diabetes mellitus (T2DM), is driven by vascular dysfunction, metabolic reprogramming, and oxidative stress. NAD+-dependent deacetylase SIRT6, located in the nucleus, is recognized for its role in modulating cardiovascular and metabolic homeostasis...

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Main Authors: Kemiao Pang, Jiayi Huang, Shiwu Zhang, Yinghui Guan, Ning Zou, Jiaxin Kang, Haining Du, Dechao Zhao, Denis V. Abramochkin, Heyu Chen, Nan Zhang, Yunyan Gu, Ning Liu, Yining Niu, Ziqi Xiong, Xueya Zhang, Fanghao Lu, Huitao Fan, Jinwei Tian, Bo Yu, Shuijie Li, Weihua Zhang
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Redox Biology
Subjects:
Type 2 diabetes (T2D)
Cell proliferation
Sirtuin 6 (SIRT6)
Hydrogen sulfide (H2S)
Glycolysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725002496
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