Imparting aromaticity to 2-pyridone derivatives by O-alkylation resulted in new competitive and non-competitive PIM-1 kinase inhibitors with caspase-activated apoptosis

Imparting aromaticity to 2-pyridone derivatives by O-alkylation resulted in new competitive and non-competitive PIM-1 kinase inhibitors with caspase-activated apoptosis

New aromatic O-alkyl pyridine derivatives were designed and synthesised as Proviral Integration Moloney (PIM)-1 kinase inhibitors. 4c and 4f showed potent in vitro anticancer activity against NFS-60, HepG-2, PC-3, and Caco-2 cell lines and low toxicity against normal human lung fibroblast Wi-38 cell...

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Bibliographic Details
Main Authors: Marwa E. Abdelaziz, Mostafa M. M. El-Miligy, Salwa M. Fahmy, Marwa M. Abu-Serie, Aly A. Hazzaa, Mona A. Mahran
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Pyridine
anticancer
apoptosis induction
caspase 3/7 activation
PIM-1 kinase inhibitors
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2024.2304044
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https://www.tandfonline.com/doi/10.1080/14756366.2024.2304044

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