Causal Effects Between Genetically Determined Human Serum Metabolite Levels on the Risk of Idiopathic Pulmonary Fibrosis: A Mendelian Randomization Study
ABSTRACT Background The incidence of idiopathic pulmonary fibrosis (IPF) is increasing every year; however, the potential biological mechanisms have not been completely clarified. The objective of this study is to reveal the etiologic effects of circulating metabolites on IPF. Methods This research...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-06-01
|
| Series: | The Clinical Respiratory Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/crj.70087 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849419079031455744 |
|---|---|
| author | Yu Shi Shuang Chen Zhaokai Zhou Mengke Huang Yue Li Xiaogang Jing |
| author_facet | Yu Shi Shuang Chen Zhaokai Zhou Mengke Huang Yue Li Xiaogang Jing |
| author_sort | Yu Shi |
| collection | DOAJ |
| description | ABSTRACT Background The incidence of idiopathic pulmonary fibrosis (IPF) is increasing every year; however, the potential biological mechanisms have not been completely clarified. The objective of this study is to reveal the etiologic effects of circulating metabolites on IPF. Methods This research evaluated the causal relationship between serum metabolites and IPF utilizing two‐sample Mendelian randomization (MR) analysis. IVW served as the main method of analysis; concurrently, MR‐Egger, weighted median, and MR‐PRESSO acted as supplementary analyses. Sensitivity analyses were performed with Cochran's Q test, MR‐Egger's intercept test, and leave‐one‐out method of analysis. All statistical analyses were accomplished in R software. Results Our results showed that 23 metabolites have a causal connection with IPF. Following sensitivity analysis, 2 robust and 12 potential causal association pairs were identified among the known metabolites. These 14 causal pairs concerned six metabolites. Conclusion This study presents a novel perspective on potential mechanisms involved in IPF with important significance for screening, prevention, and treatment. |
| format | Article |
| id | doaj-art-e14eb64c7490427088f6c36070dffe59 |
| institution | Kabale University |
| issn | 1752-6981 1752-699X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Clinical Respiratory Journal |
| spelling | doaj-art-e14eb64c7490427088f6c36070dffe592025-08-20T03:32:15ZengWileyThe Clinical Respiratory Journal1752-69811752-699X2025-06-01196n/an/a10.1111/crj.70087Causal Effects Between Genetically Determined Human Serum Metabolite Levels on the Risk of Idiopathic Pulmonary Fibrosis: A Mendelian Randomization StudyYu Shi0Shuang Chen1Zhaokai Zhou2Mengke Huang3Yue Li4Xiaogang Jing5Department of Respiration The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan ChinaCenter of Reproductive Medicine The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan ChinaDepartment of Urology The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan ChinaDepartment of Respiration The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan ChinaDepartment of Respiration The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan ChinaDepartment of Respiration The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan ChinaABSTRACT Background The incidence of idiopathic pulmonary fibrosis (IPF) is increasing every year; however, the potential biological mechanisms have not been completely clarified. The objective of this study is to reveal the etiologic effects of circulating metabolites on IPF. Methods This research evaluated the causal relationship between serum metabolites and IPF utilizing two‐sample Mendelian randomization (MR) analysis. IVW served as the main method of analysis; concurrently, MR‐Egger, weighted median, and MR‐PRESSO acted as supplementary analyses. Sensitivity analyses were performed with Cochran's Q test, MR‐Egger's intercept test, and leave‐one‐out method of analysis. All statistical analyses were accomplished in R software. Results Our results showed that 23 metabolites have a causal connection with IPF. Following sensitivity analysis, 2 robust and 12 potential causal association pairs were identified among the known metabolites. These 14 causal pairs concerned six metabolites. Conclusion This study presents a novel perspective on potential mechanisms involved in IPF with important significance for screening, prevention, and treatment.https://doi.org/10.1111/crj.70087causalityidiopathic pulmonary fibrosisMendelian randomizationserum metabolites |
| spellingShingle | Yu Shi Shuang Chen Zhaokai Zhou Mengke Huang Yue Li Xiaogang Jing Causal Effects Between Genetically Determined Human Serum Metabolite Levels on the Risk of Idiopathic Pulmonary Fibrosis: A Mendelian Randomization Study The Clinical Respiratory Journal causality idiopathic pulmonary fibrosis Mendelian randomization serum metabolites |
| title | Causal Effects Between Genetically Determined Human Serum Metabolite Levels on the Risk of Idiopathic Pulmonary Fibrosis: A Mendelian Randomization Study |
| title_full | Causal Effects Between Genetically Determined Human Serum Metabolite Levels on the Risk of Idiopathic Pulmonary Fibrosis: A Mendelian Randomization Study |
| title_fullStr | Causal Effects Between Genetically Determined Human Serum Metabolite Levels on the Risk of Idiopathic Pulmonary Fibrosis: A Mendelian Randomization Study |
| title_full_unstemmed | Causal Effects Between Genetically Determined Human Serum Metabolite Levels on the Risk of Idiopathic Pulmonary Fibrosis: A Mendelian Randomization Study |
| title_short | Causal Effects Between Genetically Determined Human Serum Metabolite Levels on the Risk of Idiopathic Pulmonary Fibrosis: A Mendelian Randomization Study |
| title_sort | causal effects between genetically determined human serum metabolite levels on the risk of idiopathic pulmonary fibrosis a mendelian randomization study |
| topic | causality idiopathic pulmonary fibrosis Mendelian randomization serum metabolites |
| url | https://doi.org/10.1111/crj.70087 |
| work_keys_str_mv | AT yushi causaleffectsbetweengeneticallydeterminedhumanserummetabolitelevelsontheriskofidiopathicpulmonaryfibrosisamendelianrandomizationstudy AT shuangchen causaleffectsbetweengeneticallydeterminedhumanserummetabolitelevelsontheriskofidiopathicpulmonaryfibrosisamendelianrandomizationstudy AT zhaokaizhou causaleffectsbetweengeneticallydeterminedhumanserummetabolitelevelsontheriskofidiopathicpulmonaryfibrosisamendelianrandomizationstudy AT mengkehuang causaleffectsbetweengeneticallydeterminedhumanserummetabolitelevelsontheriskofidiopathicpulmonaryfibrosisamendelianrandomizationstudy AT yueli causaleffectsbetweengeneticallydeterminedhumanserummetabolitelevelsontheriskofidiopathicpulmonaryfibrosisamendelianrandomizationstudy AT xiaogangjing causaleffectsbetweengeneticallydeterminedhumanserummetabolitelevelsontheriskofidiopathicpulmonaryfibrosisamendelianrandomizationstudy |