Causal Effects Between Genetically Determined Human Serum Metabolite Levels on the Risk of Idiopathic Pulmonary Fibrosis: A Mendelian Randomization Study
ABSTRACT Background The incidence of idiopathic pulmonary fibrosis (IPF) is increasing every year; however, the potential biological mechanisms have not been completely clarified. The objective of this study is to reveal the etiologic effects of circulating metabolites on IPF. Methods This research...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-06-01
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| Series: | The Clinical Respiratory Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/crj.70087 |
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| Summary: | ABSTRACT Background The incidence of idiopathic pulmonary fibrosis (IPF) is increasing every year; however, the potential biological mechanisms have not been completely clarified. The objective of this study is to reveal the etiologic effects of circulating metabolites on IPF. Methods This research evaluated the causal relationship between serum metabolites and IPF utilizing two‐sample Mendelian randomization (MR) analysis. IVW served as the main method of analysis; concurrently, MR‐Egger, weighted median, and MR‐PRESSO acted as supplementary analyses. Sensitivity analyses were performed with Cochran's Q test, MR‐Egger's intercept test, and leave‐one‐out method of analysis. All statistical analyses were accomplished in R software. Results Our results showed that 23 metabolites have a causal connection with IPF. Following sensitivity analysis, 2 robust and 12 potential causal association pairs were identified among the known metabolites. These 14 causal pairs concerned six metabolites. Conclusion This study presents a novel perspective on potential mechanisms involved in IPF with important significance for screening, prevention, and treatment. |
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| ISSN: | 1752-6981 1752-699X |