Revealing 3D microanatomical structures of unlabeled thick cancer tissues using holotomography and virtual H&E staining

Revealing 3D microanatomical structures of unlabeled thick cancer tissues using holotomography and virtual H&E staining

Abstract In histopathology, acquiring subcellular-level three-dimensional (3D) tissue structures efficiently and without damaging the tissues during serial sectioning and staining remains a formidable challenge. We address this by integrating holotomography with deep learning and creating 3D virtual...

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Main Authors: Juyeon Park, Su-Jin Shin, Geon Kim, Hyungjoo Cho, Dongmin Ryu, Daewoong Ahn, Ji Eun Heo, Jean R. Clemenceau, Isabel Barnfather, Minji Kim, Inyeop Jang, Ji-Youn Sung, Jeong Hwan Park, Hyun-seok Min, Kwang Suk Lee, Nam Hoon Cho, Tae Hyun Hwang, YongKeun Park
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59820-0
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https://doi.org/10.1038/s41467-025-59820-0

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