CYP2D6 polymorphisms and endoxifen concentration in Chinese patients with breast cancer

CYP2D6 polymorphisms and endoxifen concentration in Chinese patients with breast cancer

Abstract Background The plasma concentration of endoxifen, the active metabolite of tamoxifen, might be affected by different CYP2D6 genotypes in patients with breast cancer, but solid evidence is still lacking in Asian patients. This prospective study aimed to investigate the relationship between C...

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Main Authors: Cong Xue, Wei Yang, Anqi Hu, Caiyun He, Hai Liao, Meiting Chen, Xin An, Shusen Wang, Zhongyu Yuan, Fei Xu, Jun Tang, Haifeng Li, Su Li, Jianyong Shao, Yanxia Shi
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Cancer
Subjects:
Breast cancer
CYP2D6
Endoxifen
Plasma concentration
Tamoxifen
Online Access:https://doi.org/10.1186/s12885-025-13791-z
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https://doi.org/10.1186/s12885-025-13791-z

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