Intestinal deguelin drives resistance to acetaminophen-induced hepatotoxicity in female mice

Intestinal deguelin drives resistance to acetaminophen-induced hepatotoxicity in female mice

Acetaminophen (APAP) overdose is a leading cause of drug-induced liver injury (DILI), with gender-specific differences in susceptibility. However, the mechanism underlying this phenomenon remains unclear. Our study reveals that the gender-specific differences in susceptibility to APAP-induced hepato...

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Bibliographic Details
Main Authors: Shenhai Gong, Yunong Zeng, Ze Wang, Yanru Li, Rong Wu, Lei Li, Hongbin Hu, Ping Qin, Zhichao Yu, Xintao Huang, Peiheng Guo, Hong Yang, Yi He, Zhibin Zhao, Weidong Xiao, Xiaoshan Zhao, Lei Gao, Shumin Cai, Zhenhua Zeng
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Gut Microbes
Subjects:
DILI
gut microbiota
gender variability
deguelin
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2024.2404138
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https://www.tandfonline.com/doi/10.1080/19490976.2024.2404138

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