Microstructural and functional abnormalities of the locus coeruleus in freezing of gait in Parkinson's disease

Microstructural and functional abnormalities of the locus coeruleus in freezing of gait in Parkinson's disease

Objective: The loss of locus coeruleus (LC)-norepinephrine system may contribute to freezing of gait (FOG) in Parkinson's disease (PD), but free-water (FW) imaging has not been applied to investigate LC microstructural degeneration in FOG. This study was to investigate the role of the LC-norepi...

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Bibliographic Details
Main Authors: Huimin Sun, Caiting Gan, Xingyue Cao, Yongsheng Yuan, Heng Zhang, Chenhui Wan, Jiaxin Shi, Xufeng Wang, Youyong Kong, Tao Feng, Kezhong Zhang
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Neurobiology of Disease
Subjects:
Locus coeruleus
Free-water imaging
Freezing of gait
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125000841
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