Current Development of Mesenchymal Stem Cell-Derived Extracellular Vesicles
Mesenchymal stem cells (MSCs) are pluripotent stem cells with self-renewal. They play a critical role in cell therapy due to their powerful immunomodulatory and regenerative effects. Recent studies suggest that one of the key therapeutic mechanisms of MSCs seems to derive from their paracrine produc...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2025-01-01
|
| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.1177/09636897241297623 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832583263536807936 |
|---|---|
| author | Bingyi Zheng Xueting Wang Meizhai Guo Chi-Meng Tzeng |
| author_facet | Bingyi Zheng Xueting Wang Meizhai Guo Chi-Meng Tzeng |
| author_sort | Bingyi Zheng |
| collection | DOAJ |
| description | Mesenchymal stem cells (MSCs) are pluripotent stem cells with self-renewal. They play a critical role in cell therapy due to their powerful immunomodulatory and regenerative effects. Recent studies suggest that one of the key therapeutic mechanisms of MSCs seems to derive from their paracrine product, called extracellular vesicles (EVs). The EVs contain much DNA, messenger RNA (mRNA), microRNA, and protein components, which can exert intracellular communication to target cells. In clinical applications, the MSC-EVs have been widely used in tissue repair and immune disorder diseases. However, there are serval issues need to be considered such as how to accomplish the large-scale production of EVs and how to verify the exact mechanism of EVs. In this review, we summarize the current progress of MSC-EVs and discuss the challenges and future of MSC-EVs. |
| format | Article |
| id | doaj-art-e11af082a876422c91e834c38d5971bb |
| institution | Kabale University |
| issn | 1555-3892 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cell Transplantation |
| spelling | doaj-art-e11af082a876422c91e834c38d5971bb2025-01-28T22:03:27ZengSAGE PublishingCell Transplantation1555-38922025-01-013410.1177/09636897241297623Current Development of Mesenchymal Stem Cell-Derived Extracellular VesiclesBingyi Zheng0Xueting Wang1Meizhai Guo2Chi-Meng Tzeng3Translational Medicine Research Center, School of Pharmaceutical Sciences, Xiamen University, Xiamen, ChinaTranslational Medicine Research Center, School of Pharmaceutical Sciences, Xiamen University, Xiamen, ChinaTranslational Medicine Research Center, School of Pharmaceutical Sciences, Xiamen University, Xiamen, ChinaTranslational Medicine Research Center, School of Pharmaceutical Sciences, Xiamen University, Xiamen, ChinaMesenchymal stem cells (MSCs) are pluripotent stem cells with self-renewal. They play a critical role in cell therapy due to their powerful immunomodulatory and regenerative effects. Recent studies suggest that one of the key therapeutic mechanisms of MSCs seems to derive from their paracrine product, called extracellular vesicles (EVs). The EVs contain much DNA, messenger RNA (mRNA), microRNA, and protein components, which can exert intracellular communication to target cells. In clinical applications, the MSC-EVs have been widely used in tissue repair and immune disorder diseases. However, there are serval issues need to be considered such as how to accomplish the large-scale production of EVs and how to verify the exact mechanism of EVs. In this review, we summarize the current progress of MSC-EVs and discuss the challenges and future of MSC-EVs.https://doi.org/10.1177/09636897241297623 |
| spellingShingle | Bingyi Zheng Xueting Wang Meizhai Guo Chi-Meng Tzeng Current Development of Mesenchymal Stem Cell-Derived Extracellular Vesicles Cell Transplantation |
| title | Current Development of Mesenchymal Stem Cell-Derived Extracellular Vesicles |
| title_full | Current Development of Mesenchymal Stem Cell-Derived Extracellular Vesicles |
| title_fullStr | Current Development of Mesenchymal Stem Cell-Derived Extracellular Vesicles |
| title_full_unstemmed | Current Development of Mesenchymal Stem Cell-Derived Extracellular Vesicles |
| title_short | Current Development of Mesenchymal Stem Cell-Derived Extracellular Vesicles |
| title_sort | current development of mesenchymal stem cell derived extracellular vesicles |
| url | https://doi.org/10.1177/09636897241297623 |
| work_keys_str_mv | AT bingyizheng currentdevelopmentofmesenchymalstemcellderivedextracellularvesicles AT xuetingwang currentdevelopmentofmesenchymalstemcellderivedextracellularvesicles AT meizhaiguo currentdevelopmentofmesenchymalstemcellderivedextracellularvesicles AT chimengtzeng currentdevelopmentofmesenchymalstemcellderivedextracellularvesicles |