Current Development of Mesenchymal Stem Cell-Derived Extracellular Vesicles

Mesenchymal stem cells (MSCs) are pluripotent stem cells with self-renewal. They play a critical role in cell therapy due to their powerful immunomodulatory and regenerative effects. Recent studies suggest that one of the key therapeutic mechanisms of MSCs seems to derive from their paracrine produc...

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Main Authors: Bingyi Zheng, Xueting Wang, Meizhai Guo, Chi-Meng Tzeng
Format: Article
Language:English
Published: SAGE Publishing 2025-01-01
Series:Cell Transplantation
Online Access:https://doi.org/10.1177/09636897241297623
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author Bingyi Zheng
Xueting Wang
Meizhai Guo
Chi-Meng Tzeng
author_facet Bingyi Zheng
Xueting Wang
Meizhai Guo
Chi-Meng Tzeng
author_sort Bingyi Zheng
collection DOAJ
description Mesenchymal stem cells (MSCs) are pluripotent stem cells with self-renewal. They play a critical role in cell therapy due to their powerful immunomodulatory and regenerative effects. Recent studies suggest that one of the key therapeutic mechanisms of MSCs seems to derive from their paracrine product, called extracellular vesicles (EVs). The EVs contain much DNA, messenger RNA (mRNA), microRNA, and protein components, which can exert intracellular communication to target cells. In clinical applications, the MSC-EVs have been widely used in tissue repair and immune disorder diseases. However, there are serval issues need to be considered such as how to accomplish the large-scale production of EVs and how to verify the exact mechanism of EVs. In this review, we summarize the current progress of MSC-EVs and discuss the challenges and future of MSC-EVs.
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institution Kabale University
issn 1555-3892
language English
publishDate 2025-01-01
publisher SAGE Publishing
record_format Article
series Cell Transplantation
spelling doaj-art-e11af082a876422c91e834c38d5971bb2025-01-28T22:03:27ZengSAGE PublishingCell Transplantation1555-38922025-01-013410.1177/09636897241297623Current Development of Mesenchymal Stem Cell-Derived Extracellular VesiclesBingyi Zheng0Xueting Wang1Meizhai Guo2Chi-Meng Tzeng3Translational Medicine Research Center, School of Pharmaceutical Sciences, Xiamen University, Xiamen, ChinaTranslational Medicine Research Center, School of Pharmaceutical Sciences, Xiamen University, Xiamen, ChinaTranslational Medicine Research Center, School of Pharmaceutical Sciences, Xiamen University, Xiamen, ChinaTranslational Medicine Research Center, School of Pharmaceutical Sciences, Xiamen University, Xiamen, ChinaMesenchymal stem cells (MSCs) are pluripotent stem cells with self-renewal. They play a critical role in cell therapy due to their powerful immunomodulatory and regenerative effects. Recent studies suggest that one of the key therapeutic mechanisms of MSCs seems to derive from their paracrine product, called extracellular vesicles (EVs). The EVs contain much DNA, messenger RNA (mRNA), microRNA, and protein components, which can exert intracellular communication to target cells. In clinical applications, the MSC-EVs have been widely used in tissue repair and immune disorder diseases. However, there are serval issues need to be considered such as how to accomplish the large-scale production of EVs and how to verify the exact mechanism of EVs. In this review, we summarize the current progress of MSC-EVs and discuss the challenges and future of MSC-EVs.https://doi.org/10.1177/09636897241297623
spellingShingle Bingyi Zheng
Xueting Wang
Meizhai Guo
Chi-Meng Tzeng
Current Development of Mesenchymal Stem Cell-Derived Extracellular Vesicles
Cell Transplantation
title Current Development of Mesenchymal Stem Cell-Derived Extracellular Vesicles
title_full Current Development of Mesenchymal Stem Cell-Derived Extracellular Vesicles
title_fullStr Current Development of Mesenchymal Stem Cell-Derived Extracellular Vesicles
title_full_unstemmed Current Development of Mesenchymal Stem Cell-Derived Extracellular Vesicles
title_short Current Development of Mesenchymal Stem Cell-Derived Extracellular Vesicles
title_sort current development of mesenchymal stem cell derived extracellular vesicles
url https://doi.org/10.1177/09636897241297623
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