Multi-tissue metabolomics reveal mtDNA- and diet-specific metabolite profiles in a mouse model of cardiometabolic disease

Multi-tissue metabolomics reveal mtDNA- and diet-specific metabolite profiles in a mouse model of cardiometabolic disease

Rationale: Excess consumption of sugar- and fat-rich foods has heightened the prevalence of cardiometabolic disease, which remains a driver of cardiovascular disease- and type II diabetes-related mortality globally. Skeletal muscle insulin resistance is an early feature of cardiometabolic disease an...

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Bibliographic Details
Main Authors: Abhishek Shastry, Mia S. Wilkinson, Dalia M. Miller, Michelle Kuriakose, Jennifer L.M.H. Veeneman, Matthew Ryan Smith, Charles C.T. Hindmarch, Kimberly J. Dunham-Snary
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Redox Biology
Subjects:
Mitochondrial genetics
Cardiometabolic disease
Metabolomics
Mitochondrial-nuclear eXchange
Disease susceptibility
Skeletal muscle
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725000540
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