A Multispecific Checkpoint Inhibitor Nanofitin with a Fast Tumor Accumulation Property and Anti-Tumor Activity in Immune Competent Mice

A Multispecific Checkpoint Inhibitor Nanofitin with a Fast Tumor Accumulation Property and Anti-Tumor Activity in Immune Competent Mice

Immune checkpoint inhibitors have revolutionized cancer treatment but remain limited by on-target/off-tumor effects that narrow their therapeutic window. Although PD-L1 is mainly expressed by tumor cells, these effects could reduce bloodstream availability and tumor accumulation of PD-L1 inhibitors....

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Bibliographic Details
Main Authors: Perrine Jacquot, Javier Muñoz-Garcia, Antoine Léger, Antoine Babuty, Manon Taupin, Laurie Fradet, Fabio Dupont, Marie-Françoise Heymann, Mathieu Cinier, Dominique Heymann
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Biomolecules
Subjects:
bispecific Nanofitin
programmed cell death-ligand 1 (PD-L1)
epidermal growth factor receptor (EGFR)
on-target/off-tumor effect
tumoral accumulation
Online Access:https://www.mdpi.com/2218-273X/15/4/471
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