Engineering CD5-targeting CAR-NK cells from peripheral blood for the treatment of CD5-positive hematological malignancies

Engineering CD5-targeting CAR-NK cells from peripheral blood for the treatment of CD5-positive hematological malignancies

Abstract Background The therapeutic application of chimeric antigen receptor (CAR) T cells in T-cell malignancies faces substantial limitations owing to fratricide and potential T cell aplasia, primarily attributed to the shared expression of target antigens, such as CD5, between normal and malignan...

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Bibliographic Details
Main Authors: Haolong Lin, Lingfeng Zhang, Tong Ge, Ning An, Yongkun Yang, Yicheng Zhang, Wei Mu
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Translational Medicine
Subjects:
Cellular immunotherapy
CAR-NK
CD5
Hematologic malignancies
Online Access:https://doi.org/10.1186/s12967-025-06432-3
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https://doi.org/10.1186/s12967-025-06432-3

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