Pathogen and human NDPK-proteins promote AML cell survival via monocyte NLRP3-inflammasome activation.

Pathogen and human NDPK-proteins promote AML cell survival via monocyte NLRP3-inflammasome activation.

A history of infection has been linked with increased risk of acute myeloid leukaemia (AML) and related myelodysplastic syndromes (MDS). Furthermore, AML and MDS patients suffer frequent infections because of disease-related impaired immunity. However, the role of infections in the development and p...

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Main Authors: Sandro Trova, Fei Lin, Santosh Lomada, Matthew Fenton, Bhavini Chauhan, Alexandra Adams, Avani Puri, Alessandro Di Maio, Thomas Wieland, Daniel Sewell, Kirstin Dick, Daniel Wiseman, Deepti P Wilks, Margaret Goodall, Mark T Drayson, Farhat L Khanim, Christopher M Bunce
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0288162&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0288162&type=printable

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