Adipose-derived stem cells using fibrin gel as a scaffold enhances post-hepatectomy liver regeneration

Adipose-derived stem cells using fibrin gel as a scaffold enhances post-hepatectomy liver regeneration

Abstract We investigated the potential of adipose-derived stem cells (ADSCs) in preventing post-hepatectomy liver failure, emphasizing the necessity of direct administration using a scaffold. A fibrin gel scaffold was employed for ADSCs (gelADSC) to assess their therapeutic impact on liver regenerat...

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Main Authors: Hiroki Imamura, Yoshito Tomimaru, Shogo Kobayashi, Akima Harada, Shunbun Kita, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Takehiro Noda, Hidenori Takahashi, Daiki Hokkoku, Takeshi Kado, Keisuke Toya, Takahiro Kodama, Shigeyoshi Saito, Iichiro Shimomura, Shigeru Miyagawa, Yuichiro Doki, Hidetoshi Eguchi
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Hepatectomy
Liver regeneration
Adipose-derived stem cell
Paracrine effect
Fibrin gel
Online Access:https://doi.org/10.1038/s41598-025-90805-7
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https://doi.org/10.1038/s41598-025-90805-7

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