Preparation of g-C<sub>3</sub>N<sub>4</sub>/Co<sub>3</sub>O<sub>4</sub>/NS-CQDs Composite Materials and Their Application in the Detection of Hydrogen Peroxide and Glucose

Preparation of g-C<sub>3</sub>N<sub>4</sub>/Co<sub>3</sub>O<sub>4</sub>/NS-CQDs Composite Materials and Their Application in the Detection of Hydrogen Peroxide and Glucose

g-C<sub>3</sub>N<sub>4</sub>, a biocompatible material, has prominent applications in biology and is ideal for nano-enzyme studies. Though reported as a peroxidase mimic, its activity remains low. This group combined N,S-doped carbon quantum dots (NS-CQDs) with g-C<sub>...

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Bibliographic Details
Main Authors: Chang Feng, Yufeng Chen, Weie Wang, Yanan Niu, Xi Cao, Yuguang Lv
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Nanomaterials
Subjects:
g-C<sub>3</sub>N<sub>4</sub>
peroxidase mimic
N,S-doped carbon quantum dots (NS-CQDs)
Co<sub>3</sub>O<sub>4</sub>
colorimetric detection
Online Access:https://www.mdpi.com/2079-4991/15/10/752
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Summary:g-C<sub>3</sub>N<sub>4</sub>, a biocompatible material, has prominent applications in biology and is ideal for nano-enzyme studies. Though reported as a peroxidase mimic, its activity remains low. This group combined N,S-doped carbon quantum dots (NS-CQDs) with g-C<sub>3</sub>N<sub>4</sub> (7NSC-g), verifying its peroxidase-like activity. Based on this, a ternary composite of Co<sub>3</sub>O<sub>4</sub> in different forms and 7NSC-g was developed to enhance peroxidase activity, to design a g-C<sub>3</sub>N<sub>4</sub>-based composite enzyme. Characterizations determined the composition and morphology. Colorimetry evaluated peroxidase activity, where the simulated enzyme catalyzes blue product formation from the TMB substrate in the presence of H<sub>2</sub>O<sub>2</sub>. UV-Vis spectrophotometry measured absorbance changes to determine target concentrations. The results show Co<sub>3</sub>O<sub>4</sub> doping improves catalytic activity, with larger specific surface area providing more activation sites. The highest activity of g-C<sub>3</sub>N<sub>4</sub>/NS-CQDs/Co<sub>3</sub>O<sub>4</sub> was at 5% floral Co<sub>3</sub>O<sub>4</sub>, being efficient due to Co<sub>3</sub>O<sub>4</sub>’s electron-transfer acceleration and hydroxyl-radical mechanism. Under optimal conditions, the composite detected H<sub>2</sub>O<sub>2</sub> (10.0–230.0 μM, detection limit of 0.031 μM) and glucose (10.0–650.0 μM, detection limit of 1.024 μM).
ISSN:2079-4991

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