Antioxidant and Anti-Inflammatory Defenses in Huntington’s Disease: Roles of NRF2 and PGC-1α, and Therapeutic Strategies

Antioxidant and Anti-Inflammatory Defenses in Huntington’s Disease: Roles of NRF2 and PGC-1α, and Therapeutic Strategies

Huntington’s disease (HD) is a detrimental neurodegenerative disease caused by the expansion of a CAG triplet in the <i>HTT</i> gene. This mutation leads to the production of mutant Huntingtin (Htt) protein with toxic gain-of-function. The mHtt is responsible in several ways for the esta...

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Bibliographic Details
Main Authors: Francesco D’Egidio, Elvira Qosja, Fabrizio Ammannito, Skender Topi, Michele d’Angelo, Annamaria Cimini, Vanessa Castelli
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Life
Subjects:
Huntington’s disease
oxidative stress
ROS
neuroinflammation
NRF2
PGC-1α
Online Access:https://www.mdpi.com/2075-1729/15/4/577
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