Dimeric dipeptide mimetic the 1st loop of nerve growth factor of GK-6, which activates PI3K/AKT and MEK/MAPK/ERK, causes a neuronal type differentiation of PC12 cells
Dimeric dipeptide mimetic 1st loop of NGF GK-6 (10-6M) activating as phosphatidylinozitol 3-kinase/Akt and mitogen-activated protein kinase MEK/MAPK/ERK) signaling cascades causes PC12 cell differentiation into neuron-like cells. At the same time dimeric dipeptide mimetic the 4th loop of NGF GK-2 (1...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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LLC “Publisher OKI”
2017-11-01
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| Series: | Фармакокинетика и Фармакодинамика |
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| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/42 |
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| author | T. A. Antipova S. V. Nikolaev A. V. Revishchin E. A. Savchenko G. V. Pavlova T. A. Gudasheva |
| author_facet | T. A. Antipova S. V. Nikolaev A. V. Revishchin E. A. Savchenko G. V. Pavlova T. A. Gudasheva |
| author_sort | T. A. Antipova |
| collection | DOAJ |
| description | Dimeric dipeptide mimetic 1st loop of NGF GK-6 (10-6M) activating as phosphatidylinozitol 3-kinase/Akt and mitogen-activated protein kinase MEK/MAPK/ERK) signaling cascades causes PC12 cell differentiation into neuron-like cells. At the same time dimeric dipeptide mimetic the 4th loop of NGF GK-2 (10-6M), which activates only phosphatidylinozitol 3-kinase/Akt, does not possess the differentiating effect. |
| format | Article |
| id | doaj-art-e0befe7a5a984ce7a5dd41f2cbf86e76 |
| institution | DOAJ |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2017-11-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-e0befe7a5a984ce7a5dd41f2cbf86e762025-08-20T02:49:52ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302017-11-0104313541Dimeric dipeptide mimetic the 1st loop of nerve growth factor of GK-6, which activates PI3K/AKT and MEK/MAPK/ERK, causes a neuronal type differentiation of PC12 cellsT. A. Antipova0S. V. Nikolaev1A. V. Revishchin2E. A. Savchenko3G. V. Pavlova4T. A. Gudasheva5ФГБНУ «НИИ фармакологии имени В.В. Закусова»ФГБНУ «НИИ фармакологии имени В.В. Закусова»Федеральное государственное бюджетное учреждение науки Институт биологии гена Российской академии наукФедеральное государственное бюджетное учреждение науки Институт биологии гена Российской академии наукФедеральное государственное бюджетное учреждение науки Институт биологии гена Российской академии наукФГБНУ «НИИ фармакологии имени В.В. Закусова»Dimeric dipeptide mimetic 1st loop of NGF GK-6 (10-6M) activating as phosphatidylinozitol 3-kinase/Akt and mitogen-activated protein kinase MEK/MAPK/ERK) signaling cascades causes PC12 cell differentiation into neuron-like cells. At the same time dimeric dipeptide mimetic the 4th loop of NGF GK-2 (10-6M), which activates only phosphatidylinozitol 3-kinase/Akt, does not possess the differentiating effect.https://www.pharmacokinetica.ru/jour/article/view/42ngfдимерные дипептидные миметикигк-2гк-6дифференцировкарс12бета-тубулин 3ngfdimeric dipeptide mimetics of ngfdifferenciationpc12beta-tubulin iii |
| spellingShingle | T. A. Antipova S. V. Nikolaev A. V. Revishchin E. A. Savchenko G. V. Pavlova T. A. Gudasheva Dimeric dipeptide mimetic the 1st loop of nerve growth factor of GK-6, which activates PI3K/AKT and MEK/MAPK/ERK, causes a neuronal type differentiation of PC12 cells Фармакокинетика и Фармакодинамика ngf димерные дипептидные миметики гк-2 гк-6 дифференцировка рс12 бета-тубулин 3 ngf dimeric dipeptide mimetics of ngf differenciation pc12 beta-tubulin iii |
| title | Dimeric dipeptide mimetic the 1st loop of nerve growth factor of GK-6, which activates PI3K/AKT and MEK/MAPK/ERK, causes a neuronal type differentiation of PC12 cells |
| title_full | Dimeric dipeptide mimetic the 1st loop of nerve growth factor of GK-6, which activates PI3K/AKT and MEK/MAPK/ERK, causes a neuronal type differentiation of PC12 cells |
| title_fullStr | Dimeric dipeptide mimetic the 1st loop of nerve growth factor of GK-6, which activates PI3K/AKT and MEK/MAPK/ERK, causes a neuronal type differentiation of PC12 cells |
| title_full_unstemmed | Dimeric dipeptide mimetic the 1st loop of nerve growth factor of GK-6, which activates PI3K/AKT and MEK/MAPK/ERK, causes a neuronal type differentiation of PC12 cells |
| title_short | Dimeric dipeptide mimetic the 1st loop of nerve growth factor of GK-6, which activates PI3K/AKT and MEK/MAPK/ERK, causes a neuronal type differentiation of PC12 cells |
| title_sort | dimeric dipeptide mimetic the 1st loop of nerve growth factor of gk 6 which activates pi3k akt and mek mapk erk causes a neuronal type differentiation of pc12 cells |
| topic | ngf димерные дипептидные миметики гк-2 гк-6 дифференцировка рс12 бета-тубулин 3 ngf dimeric dipeptide mimetics of ngf differenciation pc12 beta-tubulin iii |
| url | https://www.pharmacokinetica.ru/jour/article/view/42 |
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