Dimeric dipeptide mimetic the 1st loop of nerve growth factor of GK-6, which activates PI3K/AKT and MEK/MAPK/ERK, causes a neuronal type differentiation of PC12 cells

Dimeric dipeptide mimetic the 1st loop of nerve growth factor of GK-6, which activates PI3K/AKT and MEK/MAPK/ERK, causes a neuronal type differentiation of PC12 cells

Dimeric dipeptide mimetic 1st loop of NGF GK-6 (10-6M) activating as phosphatidylinozitol 3-kinase/Akt and mitogen-activated protein kinase MEK/MAPK/ERK) signaling cascades causes PC12 cell differentiation into neuron-like cells. At the same time dimeric dipeptide mimetic the 4th loop of NGF GK-2 (1...

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Bibliographic Details
Main Authors: T. A. Antipova, S. V. Nikolaev, A. V. Revishchin, E. A. Savchenko, G. V. Pavlova, T. A. Gudasheva
Format: Article
Language:Russian
Published: LLC “Publisher OKI” 2017-11-01
Series:Фармакокинетика и Фармакодинамика
Subjects:
ngf
димерные дипептидные миметики
гк-2
гк-6
дифференцировка
рс12
бета-тубулин 3
dimeric dipeptide mimetics of ngf
differenciation
pc12
beta-tubulin iii
Online Access:https://www.pharmacokinetica.ru/jour/article/view/42
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