Separation-of-Function Alleles of <i>smc-5</i> Reveal Domain-Specific Defects and a Conserved Residue Critical for Genome Maintenance

Separation-of-Function Alleles of <i>smc-5</i> Reveal Domain-Specific Defects and a Conserved Residue Critical for Genome Maintenance

The SMC-5/6 complex safeguards genome stability through the coordinated action of its core SMC proteins and associated NSE subunits. NSE-1 is a key component of the complex and is essential for DNA repair, yet it remains poorly characterized in <i>Caenorhabditis elegans</i>. To further e...

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Bibliographic Details
Main Authors: Haiyan Yuan, Arome Solomon Odiba, Guiyan Liao, Ziteng Zhou, Wenxia Fang, Cheng Jin, Shaojun Li, Xihui Liu, Bin Wang
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Biomolecules
Subjects:
SMC-5/6 complex
<i>smc-5</i>
<i>Caenorhabditis elegans</i>
genome stability
NSE-1 localization
Online Access:https://www.mdpi.com/2218-273X/15/6/755
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