Shepherding DNA ends: Rif1 protects telomeres and chromosome breaks

Shepherding DNA ends: Rif1 protects telomeres and chromosome breaks

Cells have evolved conserved mechanisms to protect DNA ends, such as those at the termini of linear chromosomes, or those at DNA double-strand breaks (DSBs). In eukaryotes, DNA ends at chromosomal termini are packaged into proteinaceous structures called telomeres. Telomeres protect chromosome ends...

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Bibliographic Details
Main Authors: Mario Alberto Flores-Valdez, Gabriele A. Fontana, Julia K. Reinert, Nicolas H. Thomä, Ulrich Rass
Format: Article
Language:English
Published: Shared Science Publishers OG 2018-05-01
Series:Microbial Cell
Subjects:
genome stability
telomere homeostasis
DNA double-strand break repair pathway choice
non-homologous end-joining
DNA replication timing
Online Access:http://microbialcell.com/researcharticles/shepherding-dna-ends-rif1-protects-telomeres-and-chromosome-breaks/
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