Panaxatriol saponins exert anti-renal fibrosis by suppressing TNF-α mediated inflammation and TGF-β1/Smad3 signaling pathway

Panaxatriol saponins exert anti-renal fibrosis by suppressing TNF-α mediated inflammation and TGF-β1/Smad3 signaling pathway

Renal fibrosis is a key pathological process in the progression of chronic kidney disease (CKD). Panaxatriol saponins (PTS), the main bioactive compounds extracted from Panax notoginseng (Burk.) F.H. Chen, have demonstrated antioxidative and anti-inflammatory activities. This study aimed to investig...

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Bibliographic Details
Main Authors: Si Yi, Feiyan Li, Xin Ma, Yao Xu, Weijing Lai, Hongxi Chen, Junming Fan, Nan Mao, Sichong Ren
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Renal Failure
Subjects:
Panaxatriol saponins
chronic kidney disease
renal fibrosis
TNF-α
TGF-β1/smad3
UUO model
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2025.2516774
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