Relationship between cerebral small vessel disease and proteinopathies in the medial temporal lobe

Relationship between cerebral small vessel disease and proteinopathies in the medial temporal lobe

Abstract The medial temporal lobe (MTL) is strategically important for cognition and the pathogenesis of Alzheimer’s Disease (AD). Cerebral small vessel disease (CSVD) independently contributes to cognitive impairment and is believed to play a role in AD. CSVD and proteinopathies related to AD often...

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Main Authors: Valentina Perosa, Jan Oltmer, Francesco Bax, Maarten L. van den Berg, Corinne A. Auger, Johanna Rotta, Romain Perbet, Jean Augustinack, Matthew P. Frosch, Theresa Connors, Steven M. Greenberg, Bradley T. Hyman, Susanne J. van Veluw
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease (AD)
Arteriolosclerosis
Cerebral amyloid angiopathy (CAA)
Hippocampus
Medial Temporal lobe (MTL)
Perivascular space (PVS)
Online Access:https://doi.org/10.1186/s40478-025-02076-y
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https://doi.org/10.1186/s40478-025-02076-y

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