Optogenetic induction of TDP-43 aggregation impairs neuronal integrity and behavior in Caenorhabditis elegans

Optogenetic induction of TDP-43 aggregation impairs neuronal integrity and behavior in Caenorhabditis elegans

Abstract Background Cytoplasmic aggregation of TAR DNA binding protein 43 (TDP-43) in neurons is one of the hallmarks of TDP-43 proteinopathy. Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are closely associated with TDP-43 proteinopathy; however, it remains uncert...

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Main Authors: Kyung Hwan Park, Euihyeon Yu, Sooji Choi, Sangyeong Kim, Chanbin Park, J. Eugene Lee, Kyung Won Kim
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Translational Neurodegeneration
Subjects:
Neurodegenerative diseases
Optogenetics
OptoDroplet
TDP-43 proteinopathy
Amyotrophic lateral sclerosis
Frontotemporal lobar degeneration
Online Access:https://doi.org/10.1186/s40035-025-00480-x
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https://doi.org/10.1186/s40035-025-00480-x

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