Conformational variability in the D2 loop of Plasmodium Apical Membrane antigen 1

Conformational variability in the D2 loop of Plasmodium Apical Membrane antigen 1

Apical Membrane Antigen 1 (AMA1) plays a vital role in the invasion of the host erythrocyte by the malaria parasite, Plasmodium. It is thus an important target for vaccine and anti-malaria therapeutic strategies that block the invasion process. AMA1, present on the surface of the parasite, interacts...

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Bibliographic Details
Main Authors: Frederick A. Saul, Brigitte Vulliez-Le Normand, Alexander Boes, Holger Spiegel, Clemens H.M. Kocken, Bart W. Faber, Graham A. Bentley
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Journal of Structural Biology: X
Subjects:
Apical Membrane Antigen 1
Domain 2 loop
Variable conformation
Plasmodium antigen
Malaria vaccine candidate
Online Access:http://www.sciencedirect.com/science/article/pii/S2590152424000151
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