Bioanalytical method validation to quantify ketorolac in human vitreous and aqueous via surrogate matrix of human plasma

Bioanalytical method validation to quantify ketorolac in human vitreous and aqueous via surrogate matrix of human plasma

Purpose Intracameral phenylephrine 1.0%/ketorolac 0.3% (OMIDRIA®) is used during cataract surgery to prevent intraoperative miosis and reduce postoperative pain. Although studied in beagles, no human data exist showing the duration ketorolac remains in the eye postoperatively. A clinical trial measu...

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Bibliographic Details
Main Authors: Prajita Pandey, Brianna A. White, Colin Goswell, Neelanjan Bose, Sara Butterworth Connell, Nicolee Schulze, Jim Nevelos, Ana Najafi, Ramin Najafi, Ryan K. Cheu
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Future Science OA
Subjects:
Surrogate matrix
validation study
liquid chromatography-tandem mass spectrometry
OMIDRIA
phenylephrine/ketorolac
ketorolac
Online Access:https://www.tandfonline.com/doi/10.1080/20565623.2025.2476866
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https://www.tandfonline.com/doi/10.1080/20565623.2025.2476866

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