Histone methyltransferase ASH1L primes metastases and metabolic reprogramming of macrophages in the bone niche

Histone methyltransferase ASH1L primes metastases and metabolic reprogramming of macrophages in the bone niche

Abstract Bone metastasis is a major cause of cancer death; however, the epigenetic determinants driving this process remain elusive. Here, we report that histone methyltransferase ASH1L is genetically amplified and is required for bone metastasis in men with prostate cancer. ASH1L rewires histone me...

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Main Authors: Chenling Meng, Kevin Lin, Wei Shi, Hongqi Teng, Xinhai Wan, Anna DeBruine, Yin Wang, Xin Liang, Javier Leo, Feiyu Chen, Qianlin Gu, Jie Zhang, Vivien Van, Kiersten L. Maldonado, Boyi Gan, Li Ma, Yue Lu, Di Zhao
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59381-2
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https://doi.org/10.1038/s41467-025-59381-2

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