Vitamin D3 affects liver expression of pro-/anti-inflammatory cytokines and nitric oxide synthases in type 2 diabetes

Vitamin D3 affects liver expression of pro-/anti-inflammatory cytokines and nitric oxide synthases in type 2 diabetes

Our objective was to study the effect of vitamin D3 (VD) on hepatocellular oxidative-nitrosative stress and pro/anti-inflammatory cytokines in relation to nitric oxide (NO) formation and NO synthase (NOS) levels in type 2 diabetes mellitus (T2DM). After T2DM induction by high-fat diet and a single s...

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Main Authors: Ihor Shymanskyi, Olha Lisakovska, Mykola Veliky, Olha Mezhenska, Vasyl Bilous, Andrii Siromolot, Anna Khomenko, Dmytro Labudzynskyi, Tetyana Horid’ko, Elvira Pasichna
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Experimental Biology and Medicine
Subjects:
type 2 diabetes mellitus
liver dysfunction
vitamin D3
nitric oxide
oxidative-nitrosative stress
inflammatory cytokines
Online Access:https://www.ebm-journal.org/articles/10.3389/ebm.2025.10456/full
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https://www.ebm-journal.org/articles/10.3389/ebm.2025.10456/full

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