Plasmodium falciparum egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier model

Plasmodium falciparum egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier model

Abstract Cerebral malaria is a severe neurovascular complication of Plasmodium falciparum infection, with high mortality rates even after treatment with effective antimalarials. Limitations in current experimental models have hindered our knowledge of the disease. We developed a 3D blood-brain barri...

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Main Authors: Livia Piatti, Alina Batzilla, Fumio Nakaki, Hannah Fleckenstein, François Korbmacher, Rory K. M. Long, Daniel Schraivogel, John A. Hawkins, Tais Romero-Uruñuela, Borja López-Gutiérrez, Silvia Sanz Sender, Yannick Schwab, Lars M. Steinmetz, James Sharpe, Maria Bernabeu
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62514-2
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https://doi.org/10.1038/s41467-025-62514-2

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