Similar deficiencies, different outcomes: succinate dehydrogenase loss in adrenal medulla vs. fibroblast cell culture models of paraganglioma

Similar deficiencies, different outcomes: succinate dehydrogenase loss in adrenal medulla vs. fibroblast cell culture models of paraganglioma

Abstract Heterozygosity for loss-of‐function alleles of the genes encoding the four subunits of succinate dehydrogenase (SDHA, SDHB, SDHC, SDHD), as well as the SDHAF2 assembly factor predispose affected individuals to pheochromocytoma and paraganglioma (PPGL), two rare neuroendocrine tumors that ar...

Full description

Saved in:
Bibliographic Details
Main Authors: Fatimah J. Al Khazal, Sanjana Mahadev Bhat, Yuxiang Zhu, Cristina M. de Araujo Correia, Sherry X. Zhou, Brandon A. Wilbanks, Clifford D. Folmes, Gary C. Sieck, Judith Favier, L. James Maher
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cancer & Metabolism
Subjects:
Succinate dehydrogenase
Pheochromocytoma
Paraganglioma
Tricarboxylic acid cycle
Hypoxia
Complex I
Online Access:https://doi.org/10.1186/s40170-024-00369-9
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s40170-024-00369-9

Similar Items