A Critical Overview of Systematic Reviews of Shenfu Injection for Heart Failure
Objectives. Shenfu Injection (SFI) was widely used in the treatment of heart failure (HF) in China. A plethora of systematic reviews/meta-analyses (SRs/MAs) has been conducted in this research area, although with scattered results. The purpose of this overview was to conduct a comprehensive review t...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Cardiovascular Therapeutics |
| Online Access: | http://dx.doi.org/10.1155/2021/8816590 |
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| author | Jinke Huang Yanlu Wang Suihe Huang Xiaohui Qin Fang Yan Min Shen Yong Huang |
| author_facet | Jinke Huang Yanlu Wang Suihe Huang Xiaohui Qin Fang Yan Min Shen Yong Huang |
| author_sort | Jinke Huang |
| collection | DOAJ |
| description | Objectives. Shenfu Injection (SFI) was widely used in the treatment of heart failure (HF) in China. A plethora of systematic reviews/meta-analyses (SRs/MAs) has been conducted in this research area, although with scattered results. The purpose of this overview was to conduct a comprehensive review to summarize and critically evaluate the existing evidence. Methods. Digital databases were searched for SRs/MAs up to January 28, 2021. Two authors independently screened the reviews and assessed the methodological quality of included SRs/MAs using Assessing the Methodological Quality of Systematic Reviews 2 (AMSTAR-2). Quality of evidence for outcomes evaluated within the reviews was appraised with the Grading of Recommendation, Assessment, Development, and Evaluation (GRADE). Results. Thirteen SRs/MAs met the inclusion criteria. Based on AMSTAR-2, the quality of all SRs/MAs was critically low, because all of them have more than one critical domains that were unmet. Based on GRADE, the evidence quality of 24 outcome measures was low or very low, 27 outcome measures was moderate, and none outcome measure was high. Descriptive analysis showed that SFI was an effective and safe method for HF. Conclusions. The use of SFI for the treatment of HF may be clinically effective and safe. However, this conclusion must be interpreted cautiously due to the generally low methodological quality and low evidence quality of the included SRs/MAs. More rigorously designed SRs/MAs and RCTs with high methodological quality are necessary for further proof. |
| format | Article |
| id | doaj-art-e01648e5e4fa4e51b25df1575b9f3bfb |
| institution | OA Journals |
| issn | 1755-5914 1755-5922 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiovascular Therapeutics |
| spelling | doaj-art-e01648e5e4fa4e51b25df1575b9f3bfb2025-08-20T02:21:07ZengWileyCardiovascular Therapeutics1755-59141755-59222021-01-01202110.1155/2021/88165908816590A Critical Overview of Systematic Reviews of Shenfu Injection for Heart FailureJinke Huang0Yanlu Wang1Suihe Huang2Xiaohui Qin3Fang Yan4Min Shen5Yong Huang6The Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province 510120, ChinaThe First Clinical Medical College of Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province 255014, ChinaResearch Base of the Clinical Application of Traditional Chinese Medicine Classics, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong Province 510120, ChinaDepartment of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong Province 510120, ChinaResearch Base of the Clinical Application of Traditional Chinese Medicine Classics, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong Province 510120, ChinaThe Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province 510120, ChinaSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong Province 510515, ChinaObjectives. Shenfu Injection (SFI) was widely used in the treatment of heart failure (HF) in China. A plethora of systematic reviews/meta-analyses (SRs/MAs) has been conducted in this research area, although with scattered results. The purpose of this overview was to conduct a comprehensive review to summarize and critically evaluate the existing evidence. Methods. Digital databases were searched for SRs/MAs up to January 28, 2021. Two authors independently screened the reviews and assessed the methodological quality of included SRs/MAs using Assessing the Methodological Quality of Systematic Reviews 2 (AMSTAR-2). Quality of evidence for outcomes evaluated within the reviews was appraised with the Grading of Recommendation, Assessment, Development, and Evaluation (GRADE). Results. Thirteen SRs/MAs met the inclusion criteria. Based on AMSTAR-2, the quality of all SRs/MAs was critically low, because all of them have more than one critical domains that were unmet. Based on GRADE, the evidence quality of 24 outcome measures was low or very low, 27 outcome measures was moderate, and none outcome measure was high. Descriptive analysis showed that SFI was an effective and safe method for HF. Conclusions. The use of SFI for the treatment of HF may be clinically effective and safe. However, this conclusion must be interpreted cautiously due to the generally low methodological quality and low evidence quality of the included SRs/MAs. More rigorously designed SRs/MAs and RCTs with high methodological quality are necessary for further proof.http://dx.doi.org/10.1155/2021/8816590 |
| spellingShingle | Jinke Huang Yanlu Wang Suihe Huang Xiaohui Qin Fang Yan Min Shen Yong Huang A Critical Overview of Systematic Reviews of Shenfu Injection for Heart Failure Cardiovascular Therapeutics |
| title | A Critical Overview of Systematic Reviews of Shenfu Injection for Heart Failure |
| title_full | A Critical Overview of Systematic Reviews of Shenfu Injection for Heart Failure |
| title_fullStr | A Critical Overview of Systematic Reviews of Shenfu Injection for Heart Failure |
| title_full_unstemmed | A Critical Overview of Systematic Reviews of Shenfu Injection for Heart Failure |
| title_short | A Critical Overview of Systematic Reviews of Shenfu Injection for Heart Failure |
| title_sort | critical overview of systematic reviews of shenfu injection for heart failure |
| url | http://dx.doi.org/10.1155/2021/8816590 |
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