Identification of polyphosphate-binding proteins in Escherichia coli uncovers targets involved in translation control and ribosome biogenesis

Identification of polyphosphate-binding proteins in Escherichia coli uncovers targets involved in translation control and ribosome biogenesis

ABSTRACT In many bacteria, polyphosphate kinase (PPK) enzymes use ATP to synthesize polyphosphate (polyP) in response to cellular stress. These chains of inorganic phosphates are joined by high-energy bonds and can reach hundreds of residues in length. PolyP plays diverse functions in helping bacter...

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Main Authors: Kanchi Baijal, Brianna Kore, Iryna Abramchuk, Alix Denoncourt, Shauna Han, Abby Simms, Amy Dagenais, Abagail R. Long, Adam D. Rudner, Mathieu Lavallée-Adam, Michael J. Gray, Michael Downey
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:mBio
Subjects:
polyphosphate
E. coli
polyP-binding proteins
ribosome
stress response
PPK
Online Access:https://journals.asm.org/doi/10.1128/mbio.00500-25
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https://journals.asm.org/doi/10.1128/mbio.00500-25

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