Unveiling therapeutic targets and preventive components for kidney insufficiency and blood stasis-type BPH: bridging metabolomics, network pharmacology and reverse screening

Unveiling therapeutic targets and preventive components for kidney insufficiency and blood stasis-type BPH: bridging metabolomics, network pharmacology and reverse screening

Benign prostatic hyperplasia (BPH) is a common disease affecting male urinary system function and quality of life, with its incidence increasing due to population ageing and unhealthy lifestyles. Modern medicine mainly adopts symptomatic treatments such as 5-alpha reductase inhibitors and alpha1 adr...

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Main Authors: Xiangpeng Kong, Haiqin Ren, Ke Pei, Yajun Yao, Zhigang Liang, Yunfeng Xue, Shuang Liang, Tongtong Li, Jing Zhang, Yuxia Guo, Miaorong Pei, Huifeng Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
benign prostatic hyperplasia (BPH)
kidney insufficiency and blood stasis
metabolomics
network pharmacology
integration
target
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1584766/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1584766/full

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