Pan-cancer analysis identifies CD155 as a promising target for CAR-T cell therapy

Pan-cancer analysis identifies CD155 as a promising target for CAR-T cell therapy

Abstract Background Chimeric antigen receptor T (CAR-T) cell therapy has shown remarkable success in treating hematologic malignancies. However, its efficacy against solid tumors remains limited. One of the major challenges is the lack of specific tumor antigens. Therefore, the exploration and ratio...

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Bibliographic Details
Main Authors: Xiaohong Liu, Yue Sun, Boxu Lin, Hao Xiong, Xinyue Lu, Binghe Tan, Chenglin Zhang, Mingyao Liu, Juliang Qin, Na Zhang, Bing Du
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Genome Medicine
Subjects:
CD155/PVR
TIGIT
CAR-T
Pan-cancer
Targets
Online Access:https://doi.org/10.1186/s13073-025-01490-0
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https://doi.org/10.1186/s13073-025-01490-0

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