Pharmacokinetics of levosimendan in critically Ill children on extracorporeal membrane oxygenation: a prospective observational study

Pharmacokinetics of levosimendan in critically Ill children on extracorporeal membrane oxygenation: a prospective observational study

BackgroundLevosimendan is used off-label in pediatrics and pharmacokinetic (PK) data in this population are scarce. The only study in critically ill patients on extracorporeal membrane oxygenation (ECMO) showed altered PK parameters. Our study aimed to characterize the PK profile of levosimendan and...

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Main Authors: Stéphane Bertin, David Haefliger, Maria-Helena Perez, Monia Guidi, Laurent A. Decosterd, Vivianne Chanez, Ermindo R. Di Paolo, Thierry Buclin, Françoise Livio
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pediatrics
Subjects:
levosimendan
extracorporeal membrane oxygenation
pediatrics
infant
pharmacokinetics
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2025.1542417/full
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https://www.frontiersin.org/articles/10.3389/fped.2025.1542417/full

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