Non-nucleophilic base promoted synthesis of azo-linked oxazolone-pyrazole hybrids: Antimicrobial, antitubercular, anticancer evaluations and in-silico modeling insights

Non-nucleophilic base promoted synthesis of azo-linked oxazolone-pyrazole hybrids: Antimicrobial, antitubercular, anticancer evaluations and in-silico modeling insights

Ten new non-nucleophilic base (DBU) catalyzed oxazolone-bearing pyrazole derivatives were created to treat infectious diseases caused by bacterial, mycobacterial strains, and cancerous cell lines. Compounds 7b and 7c showed excellent antibacterial and antifungal activity. Compound 7b was highly effe...

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Main Authors: Bonny Y. Patel, Vidhi Joshi, Sangeetha Subramanian, Gopal Italiya, Prasanna Srinivasan Ramalingam, Sivakumar Arumugam, Sanjay D. Hadiyal, Al-Anood Mohamed Al-Dies
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Results in Chemistry
Subjects:
Anticancer
Antimicrobial
Antitubercular
Molecular docking
Oxazolone-pyrazole
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715624005836
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