Impact of doxycycline pre-exposure prophylaxis (doxyPrEP) for sexually transmitted infections on the microbiome of men who have sex with men on HIV PrEP

Impact of doxycycline pre-exposure prophylaxis (doxyPrEP) for sexually transmitted infections on the microbiome of men who have sex with men on HIV PrEP

Abstract Doxycycline pre-exposure prophylaxis (doxyPrEP) has shown potential in preventing bacterial sexually transmitted infections, but the impact on the microbiome is unknown. This study assessed rectal microbiome changes over 48 weeks in 41 participants on HIV PrEP (tenofovir disoproxil fumarate...

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Main Authors: Samantha Knodel, Leighanne Main, Marlon DeLeon, Alana Lamont, Joshua Edward, Amit K. Gupta, Laura Noel-Romas, Saira Mohammed, Tessa Tattersall, Jason Wong, Mark Hull, Troy Grennan, Adam D. Burgener
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61426-5
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https://doi.org/10.1038/s41467-025-61426-5

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