Enhancement of carrimycin production in Streptomyces spiramyceticus 54-IA by the reporter-guided selection method with traditional mutagenesis

Enhancement of carrimycin production in Streptomyces spiramyceticus 54-IA by the reporter-guided selection method with traditional mutagenesis

Abstract Carrimycin, a new drug approved in recent years, is produced by recombinant Streptomyces spiramyceticus harboring a heterogeneous 4″-O-isovaleryltransferase gene (ist). The regulatory gene bsm42 plays a crucial role in activation of carrimycin biosynthesis, its high expression can improve t...

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Bibliographic Details
Main Authors: Kemeng Li, Jianlu Dai, Yue Chang, Tianyi Hao, Weiqing He
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Microbiology
Subjects:
Carrimycin
Streptomyces spiramyceticus
Positive regulator
Reporter gene
Online Access:https://doi.org/10.1186/s12866-025-04120-2
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https://doi.org/10.1186/s12866-025-04120-2

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