Design, synthesis, biological evaluation and in silico studies of 2-anilino- 4-(benzimidazol- 1-yl)pyrimidine scaffold as antitumor agents

Design, synthesis, biological evaluation and in silico studies of 2-anilino- 4-(benzimidazol- 1-yl)pyrimidine scaffold as antitumor agents

Abstract In an attempt to rationalize the search for new potential Chemotherapeutic agents, a new series of 2-anilinobenzimidazol derivatives with CDK activity have been synthesized. The newly synthesized compounds have been assessed for their cytotoxic effects and CDK activity. These presented comp...

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Bibliographic Details
Main Authors: Lamees S. Al-Rasheed, Siddique Akber Ansari, Hanadi H. Asiri, Ahmed H. Bakheit, Abdulrahman A. Al-mehizia, Amsha S. Alsegiani, Hamad M. Alkahtani
Format: Article
Language:English
Published: Springer 2025-05-01
Series:Saudi Pharmaceutical Journal
Subjects:
Cancer
Benzimidazole
CDK
Antitumor activity
Molecular docking
Online Access:https://doi.org/10.1007/s44446-025-00010-w
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https://doi.org/10.1007/s44446-025-00010-w

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